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#bioinformatics

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Egon Willighagen<p>yeah, that's cool</p><p>"Now, researchers have found a way to image the sugars at a resolution of just 9 Ångström — 0.9 nanometres — using an off-the-shelf light microscope." <a href="https://doi.org/10.1038/d41586-025-02376-2" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1038/d41586-025-023</span><span class="invisible">76-2</span></a> and <a href="https://doi.org/10.1038/s41565-025-01966-5" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1038/s41565-025-019</span><span class="invisible">66-5</span></a></p><p><a href="https://social.edu.nl/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://social.edu.nl/tags/sugar" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sugar</span></a></p>
Bose-Einstein-Kondensat<p><a href="https://mstdn.social/tags/MolPrint3D" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MolPrint3D</span></a>: A <a href="https://mstdn.social/tags/Blender" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Blender</span></a> add-on for enhanced <a href="https://mstdn.social/tags/3Dprinting" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>3Dprinting</span></a> of ball-and-stick <a href="https://mstdn.social/tags/molecular" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>molecular</span></a> models:<br><a href="https://doi.org/10.1021/acs.jchemed.7b00549" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1021/acs.jchemed.7b</span><span class="invisible">00549</span></a><br><a href="https://mstdn.social/tags/DIYbio" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DIYbio</span></a> <a href="https://mstdn.social/tags/chemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>chemistry</span></a> <a href="https://mstdn.social/tags/lab" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>lab</span></a> <a href="https://mstdn.social/tags/CompChem" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CompChem</span></a> <a href="https://mstdn.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://mstdn.social/tags/visualization" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>visualization</span></a> <a href="https://mstdn.social/tags/MINT" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MINT</span></a> <a href="https://mstdn.social/tags/STEM" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>STEM</span></a> <a href="https://mstdn.social/tags/EDU" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EDU</span></a> <a href="https://mstdn.social/tags/school" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>school</span></a> <a href="https://mstdn.social/tags/Schule" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Schule</span></a> <a href="https://mstdn.social/tags/education" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>education</span></a></p>
Luke Pembleton<p>On NCBI what determines which genome assembly gets the green 'reference" star tag? I'm seeming a scaffold level assembly with 40X coverage from 2019 getting the 'reference' star whilst a complete chromosome scale assembly with 300X coverage from 2021 for the same species not... Is this a community driven label that just takes time to update?<br><a href="https://genomic.social/tags/genomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>genomics</span></a> <a href="https://genomic.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a></p>
PuckerLab<p>Interested in learning about plant genomics? We're offering an opportunity for a few students to join our genomics team and gain hands-on experience in DNA extraction, ONT sequencing, and data analysis. Reach out if you're interested: <a href="https://www.pbb.uni-bonn.de" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">pbb.uni-bonn.de</span><span class="invisible"></span></a><br><a href="https://genomic.social/tags/Genomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Genomics</span></a> <a href="https://genomic.social/tags/Bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bioinformatics</span></a> <a href="https://genomic.social/tags/PlantScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PlantScience</span></a> <a href="https://genomic.social/tags/OpenScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>OpenScience</span></a><br><span class="h-card" translate="no"><a href="https://mastodon.social/@boas_pucker" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>boas_pucker</span></a></span></p>
Dave Lunt<p>Whenever I see a DNA logo from a lab, bioinformatics/genomics centre, hackathon, or training course and it’s backwards I sigh a little. I don’t point them out anymore as I usually just receive passive aggression, but what does it say about you that you don’t care? Several big ones in my stream today. If an entomology training centre had a logo with an 8-legged fly it’d be weird right? <a href="https://genomic.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://genomic.social/tags/genomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>genomics</span></a> <a href="https://genomic.social/tags/DNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DNA</span></a></p>
Victoria Stuart 🇨🇦 🏳️‍⚧️<p>GREmLN: A Cellular Regulatory Network-Aware Transcriptomics Foundation Model<br><a href="https://www.biorxiv.org/content/10.1101/2025.07.03.663009v1?rss=1" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">25.07.03.663009v1?rss=1</span></a></p><p>Comments<br>* really brilliant work: LLM + neural transformer architecture<br>* a molecular biologist, I long-thought (no time to learn / program) flux-based analysis / ODE models<br>* this type of modeling is foundational to in silico modeling<br>* huge proponent of graphs - add LLM, attention heads - brilliant! 😀 👍️ kudos</p><p><a href="https://mastodon.social/tags/BiologicalModeling" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BiologicalModeling</span></a> <a href="https://mastodon.social/tags/FoundationModels" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>FoundationModels</span></a> <a href="https://mastodon.social/tags/LLM" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LLM</span></a> <a href="https://mastodon.social/tags/attention" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>attention</span></a> <a href="https://mastodon.social/tags/GraphTheory" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>GraphTheory</span></a> <a href="https://mastodon.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a></p>
Leszek<p>Group leader position in Oslo, Norway<br><a href="https://genomic.social/tags/JobAd" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>JobAd</span></a> <a href="https://genomic.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <br><a href="https://www.jobbnorge.no/en/available-jobs/job/282908/group-leader" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">jobbnorge.no/en/available-jobs</span><span class="invisible">/job/282908/group-leader</span></a></p>
MottG<p>"Valsci: an open-source, self-hostable literature review utility for automated large-batch scientific claim verification using large language models"</p><p>We introduce Valsci, an open-source, self-hostable utility that automates large-batch scientific claim verification using any OpenAI-compatible large language model. Valsci unites RAG with structured bibliometric scoring and chain-of-thought prompting.</p><p><a href="https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-025-06159-4" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">bmcbioinformatics.biomedcentra</span><span class="invisible">l.com/articles/10.1186/s12859-025-06159-4</span></a></p><p><a href="https://researchbuzz.masto.host/tags/research" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>research</span></a> <a href="https://researchbuzz.masto.host/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://researchbuzz.masto.host/tags/medicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>medicine</span></a></p>
ISEP<p>New <a href="https://mstdn.science/tags/ISEPpapers" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ISEPpapers</span></a>! New T2T assembly of <a href="https://mstdn.science/tags/Cryptosporidium" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cryptosporidium</span></a> parvum IOWA II annotated with Legacy-Compatible Gene identifiers <a href="https://www.nature.com/articles/s41597-025-05364-3" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41597-025</span><span class="invisible">-05364-3</span></a> </p><p><a href="https://mstdn.science/tags/Protists" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Protists</span></a> <a href="https://mstdn.science/tags/Microbes" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Microbes</span></a> <a href="https://mstdn.science/tags/Parasites" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Parasites</span></a> <a href="https://mstdn.science/tags/Genomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Genomics</span></a> <a href="https://mstdn.science/tags/Bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bioinformatics</span></a> <a href="https://mstdn.science/tags/Genome" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Genome</span></a> <a href="https://mstdn.science/tags/Sequencing" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Sequencing</span></a></p>
Physalia-courses<p>🚨 Last seats alert! 🚨<br>Our GWAS course kicks off next week (23–27 June)💥<br>Learn the full pipeline—from study design to result interpretation—with hands-on sessions using R and PLINK. 💻🧬</p><p>👉 Grab your spot: <a href="https://www.physalia-courses.org/courses-workshops/course49/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">physalia-courses.org/courses-w</span><span class="invisible">orkshops/course49/</span></a></p><p><a href="https://ecoevo.social/tags/GWAS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>GWAS</span></a> <a href="https://ecoevo.social/tags/Genomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Genomics</span></a> <a href="https://ecoevo.social/tags/Bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bioinformatics</span></a> <a href="https://ecoevo.social/tags/Rstats" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Rstats</span></a></p>
Johan Nyström-Persson<p>Excited to announce our paper "Precise and scalable metagenomic profiling with sample-tailored minimizer libraries". <a href="https://academic.oup.com/nargab/article/7/2/lqaf076/8158581#522744339" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">academic.oup.com/nargab/articl</span><span class="invisible">e/7/2/lqaf076/8158581#522744339</span></a></p><p>1) We introduce a new implementation of the Kraken 2 method on Apache Spark, which has comparable cost-performance when classifying multiple samples.</p><p><a href="https://genomic.social/tags/metagenomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>metagenomics</span></a> <a href="https://genomic.social/tags/Kraken2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Kraken2</span></a> <a href="https://genomic.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a></p>
Amici Is Me 🇵🇸 🇺🇦 🇳🇴<p>Writing my own peptide cutter because I think cleaver package in R has an outdated trypsin algorithm. Getting 25 fragments on the cleaver result, while manual peptide cutter on Expasy gives 27</p><p><a href="https://fribygda.no/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a></p>
Frank Aylward<p>What's the easiest way to create a GenBank file from FASTA, GFF, BED, etc? All of the ways I know are unnecessarily difficult. </p><p>I have always avoided GenBank format, but it's unavoidable sometimes. </p><p><a href="https://genomic.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://genomic.social/tags/genomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>genomics</span></a></p>
Marc Robinson-Rechavi<p>Editorial <span class="h-card" translate="no"><a href="https://mstdn.science/@SIB" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>SIB</span></a></span> by <span class="h-card" translate="no"><a href="https://mstdn.science/@dessimoz" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>dessimoz</span></a></span> <br>"we must ensure (Switzerland's) continued science leadership – including in data expertise and infrastructure"<br><a href="https://www.sib.swiss/news/switzerlands-science-future-continued-leadership-or-drift-into-decline" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sib.swiss/news/switzerlands-sc</span><span class="invisible">ience-future-continued-leadership-or-drift-into-decline</span></a> <a href="https://ecoevo.social/tags/Switzerland" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Switzerland</span></a> <a href="https://ecoevo.social/tags/SwissScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SwissScience</span></a> <a href="https://ecoevo.social/tags/DataScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DataScience</span></a> <a href="https://ecoevo.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://ecoevo.social/tags/ScienceFunding" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ScienceFunding</span></a></p>
Eugene F. Baulin<p>📢Job Alert: Postdoctoral Researcher in the Laboratory of RNA Algorithms at <a href="https://imol.institute/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">imol.institute/</span><span class="invisible"></span></a>, up to three years, fully funded by <a href="https://ncn.gov.pl/en" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">ncn.gov.pl/en</span><span class="invisible"></span></a> </p><p>Details here: <a href="https://euraxess.ec.europa.eu/jobs/350755" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">euraxess.ec.europa.eu/jobs/350</span><span class="invisible">755</span></a> </p><p><a href="https://mastodon.social/tags/postdoc" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>postdoc</span></a> <a href="https://mastodon.social/tags/Academia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Academia</span></a> <a href="https://mastodon.social/tags/Position" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Position</span></a> <a href="https://mastodon.social/tags/Job" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Job</span></a> <a href="https://mastodon.social/tags/Research" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Research</span></a> <a href="https://mastodon.social/tags/RNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RNA</span></a> <a href="https://mastodon.social/tags/Structure" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Structure</span></a> <a href="https://mastodon.social/tags/Bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bioinformatics</span></a> <a href="https://mastodon.social/tags/Poland" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Poland</span></a> <a href="https://mastodon.social/tags/Warsaw" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Warsaw</span></a> <a href="https://mastodon.social/tags/IMolPAS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>IMolPAS</span></a> <a href="https://mastodon.social/tags/NCN" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NCN</span></a></p>
SIB Swiss Bioinformatics<p>💡 Want to make the most of cell line data? Join this <a href="https://mstdn.science/tags/BC2Basel" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BC2Basel</span></a> tutorial to explore Cellosaurus, from ontologies to APIs to real-world use cases.</p><p>🔹Taught by Amos Bairoch &amp; Pierre-André Michel (SIB).</p><p>📅 Mon 8 Sep at <a href="https://mstdn.science/tags/bc2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bc2</span></a> </p><p>👉Register: tinyurl.com/5n8w3pwb</p><p><a href="https://mstdn.science/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://mstdn.science/tags/Cellosaurus" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cellosaurus</span></a> <a href="https://mstdn.science/tags/celllines" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>celllines</span></a> <a href="https://mstdn.science/tags/lifesciences" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>lifesciences</span></a> <a href="https://mstdn.science/tags/FAIRdata" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>FAIRdata</span></a></p>
jobRxiv<p>Postdoctoral Research Scientist </p><p>Earlham Institute</p><p>Applications are invited for a Postdoctoral Research Scientist to join the Research Faculty Department at the Earlham Institute, based in Norwich, UK.</p><p>See the full job description on jobRxiv: <a href="https://jobrxiv.org/job/earlham-institute-27778-postdoctoral-research-scientist-7/?feed_id=96198" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/earlham-instit</span><span class="invisible">ute-27778-postdoctoral-research-scientist-7/?feed_id=96198</span></a></p><p><a href="https://mas.to/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://mas.to/tags/computational_biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>computational_biology</span></a> <a href="https://mas.to/tags/computational_ge" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>computational_ge</span></a>...<br><a href="https://jobrxiv.org/job/earlham-institute-27778-postdoctoral-research-scientist-7/?feed_id=96198" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/earlham-instit</span><span class="invisible">ute-27778-postdoctoral-research-scientist-7/?feed_id=96198</span></a></p>
J9C :arcgis: :python: :osm:<p><span class="h-card" translate="no"><a href="https://scicomm.xyz/@Haonan" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>Haonan</span></a></span> welcome to Mastodon! I've added some tags to help you connect. </p><p><a href="https://mapstodon.space/tags/proteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteomics</span></a> <a href="https://mapstodon.space/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://mapstodon.space/tags/database" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>database</span></a> <a href="https://mapstodon.space/tags/spectometry" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>spectometry</span></a><br><a href="https://mapstodon.space/tags/introductions" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>introductions</span></a> <a href="https://mapstodon.space/tags/stem" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>stem</span></a></p>
Marc Robinson-Rechavi<p>You can still apply: Postdoc job opportunity! We're looking for early career researcher in evolutionary genomics to study the relation between intra-specific gene expression variability, polymorphism, and macro-evolutionary rates. We have all of the data in 3 fishes and amphioxus, just waiting for your expertise and enthusiasm!<br><a href="https://tinyurl.com/3aewk286" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">tinyurl.com/3aewk286</span><span class="invisible"></span></a> <br><a href="https://ecoevo.social/tags/EvoDevo" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EvoDevo</span></a> <a href="https://ecoevo.social/tags/MolecularEvolution" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MolecularEvolution</span></a> <a href="https://ecoevo.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bioinformatics</span></a> <a href="https://ecoevo.social/tags/PopulationGenomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PopulationGenomics</span></a> <a href="https://ecoevo.social/tags/RNAseq" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RNAseq</span></a> <a href="https://ecoevo.social/tags/PostDoc" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PostDoc</span></a></p>
SMT<p><a href="https://genomic.social/tags/htslib" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>htslib</span></a> <a href="https://genomic.social/tags/Bioinformatics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bioinformatics</span></a> <a href="https://genomic.social/tags/GenomicsIO" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>GenomicsIO</span></a> <br><span class="h-card" translate="no"><a href="https://genomic.social/@yokofakun" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>yokofakun</span></a></span> any idea what is the fastest method to get the nth bcf record using htslib or bcftools.h without explicit loops? (trying out something similar to your project <a href="https://github.com/lindenb/rbcf" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">github.com/lindenb/rbcf</span><span class="invisible"></span></a> but with ALTREP) <br>I guess it is possible to guess which block to (lazy) parse if one know the blocks offsets and number of records per block</p>