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#structural

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C.

@abff08f4813c @LALegault

I'm saying compare the #decision as to whether to search this landfill to the history of similar choices made by the same #authorities, rather than to other decisions made by *different* authorities (cities, provinces).

The #hazards are significant. #Refuse has really poor #structural qualities. People are #killed every year when the hole they're digging in a landfill while looking for #valuables collapses.

re: cost - consider #opportunity #cost as well.

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Jo (she/they)

@atomicpoet@calckey.social I think whatever we become we'll really only have 'succeeded' if #Calckey leads the way with #FediverseSafety ahead of features and scale.

The Calckey I see would
- have a diverse team of folks that has the time to listen to the safety discourses, and the lived experience to know why safety matters, and informs their #development decisions.
- make importing #blocklists or integrating third party #moderation tools easypeasy, so no user finds themselves on an new server that's open to dogpiled by the worst elements of the #Fediverse.
- have robust #accessibility features that are as important to promote as #quoteposts and #MFM.
- have granular user controls for #safety - opt-in & opt-out; and features - like turning down/off MFM when it's overwhelming without a user needing to resort to CSS scripts.
- not really care to be a birdsite or #Mastodon alternative. Let's work to be a better secret third thing, or fourth, or fifth thing.

If we really have to duplicate the big influencer account thing, I'd like to see more non-White, autistic, disabled, queers, and women voices. They're here, but they're often forced to be critics of a newer hegemony. Let's be listening for how can Calckey become the main service of choice for Black, POC and Indigenous women to join, spin up servers, become developers, and have prominent voices on. The rest of the good stuff will follow that.

I think we can do that, but only if we prioritise, and promote minority voices, and do the structural work to support them coming to the service.

#FindAServer #Disability #DisabilityMastodon #Queer #structuralbarriers #structural

Know Your MemeA Secret Third ThingA Secret Third Thing, sometimes written as "A Secret, More Complex Third Thing," is a catchphrase and phrasal template popularized on Twitter in the summer of 2022 with the template, "I am neither X nor Y but a secret third thing."
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Dave nλ=2dsinθ

A chink in #AlphaFold's armour?

Using AlphaFold to predict the impact of single mutations on protein stability and function | PLOS ONE

@strucbio #Structural Biology #Alphafold #AI #Science #Research
journals.plos.org/plosone/arti

journals.plos.orgUsing AlphaFold to predict the impact of single mutations on protein stability and functionAlphaFold changed the field of structural biology by achieving three-dimensional (3D) structure prediction from protein sequence at experimental quality. The astounding success even led to claims that the protein folding problem is “solved”. However, protein folding problem is more than just structure prediction from sequence. Presently, it is unknown if the AlphaFold-triggered revolution could help to solve other problems related to protein folding. Here we assay the ability of AlphaFold to predict the impact of single mutations on protein stability (ΔΔG) and function. To study the question we extracted the pLDDT and <pLDDT> metrics from AlphaFold predictions before and after single mutation in a protein and correlated the predicted change with the experimentally known ΔΔG values. Additionally, we correlated the same AlphaFold pLDDT metrics with the impact of a single mutation on structure using a large scale dataset of single mutations in GFP with the experimentally assayed levels of fluorescence. We found a very weak or no correlation between AlphaFold output metrics and change of protein stability or fluorescence. Our results imply that AlphaFold may not be immediately applied to other problems or applications in protein folding.
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Andy @Revkin

Thanks go to earthquake-safety engineers like @KitMiyamoto, the team @geosafety team and countless others on seismic front lines spreading a safer construction culture. I would so love not to have to keep writing the same story over and over. revkin.substack.com/p/gauging-
---
RT @KitMiyamoto
Investing in #structural strengthening can save lives. Let's make sure we're doing all we can to protect our…
twitter.com/KitMiyamoto/status

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Jim Wald

@anneeroper

Yeah.

+ FFS I am all for individual action to reduce #carbon imprint and all that good stuff (I, too, try to do what I can + see the feed & blog of friend @lloydalter !)
but these petty lifestyle changes are trivial in comparison to the #structural and #institutional changes we need to make in order to save the planet.

Misplaced energy (no pun intended). Forget the pot cozy. Lobby the government and energy provider.

Public
MClare

Long overdue #introduction,

I’m a #structuralengineer and a #software developer. I tried to do both for 5+ years with an emphasis on #structural before deciding it would be a lot better for my career and happiness to focus on the #software.

I’m currently working as a #fullstackengineer. I also do contract work related to #sustainabledesign #embodiedcarbon #sustainability

Other interests:
#dataviz #bridges #emacs #foss #cats #builtenvironment

Previously @recursecenter

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