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#semaglutide

1 post1 participant0 posts today
Public
DrBob, Neurologist, 🧠Mechanic

Unique new drug for #Obesity?

BAM15, semaglutide, rosiglitazone, and pioglitazone in diet-induced obese mice 

The study compares #BAM15 with #Semaglutide, rosiglitazone, and pioglitazone in obese mice. BAM15 outperformed the others in reducing body weight, improving insulin sensitivity, enhancing glucose tolerance, and reducing liver fat and inflammation.

Its unique mechanism—mitochondrial uncoupling—increases energy expenditure rather than altering insulin pathways.

No major side effects were observed. Human research is needed.
#wegovy #ozempic #mounjaro #zepbound
sciencedirect.com/science/arti

Public
DrBob, Neurologist, 🧠Mechanic

New Review and Meta-Analysis confirms weight gain with discontinuance of #Semaglutide and #Tirzepatide

Discontinuing GLP1 medications led to a pooled overall mean weight regain of 9.69 kg (or about 22 lbs in patients prescribed semaglutide/tirzepatide. The proportion of weight regained was proportional to the amount originally lost.

Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to #Obesity.

#wegovy #ozempic #mounjaro #zepbound
onlinelibrary.wiley.com/doi/10

Text Shot: Summary Research on Glucagon-like peptide 1 receptor agonist (GLP-1RA) has mainly focused on the efficacy of weight loss and not the long-term efficacy of weight loss maintenance. This systematic review and meta-analysis aims to evaluate the sustainability of weight loss of patients taking GLP-1RAs following the discontinuation of the drug. EBSCOhost was used to simultaneously search Academic Search Premier, CINHAL Ultimate, Cochrane Central Register of Controlled Trials, MEDLINE with full text, Cochrane Database of Systematic Reviews, and separate PubMed search was systematically investigated using a predetermined search strategy from inception to February 1st, 2024. The authors extracted data regarding body weight change from baseline on treatment and off treatment, change in waist circumference from baseline on and off treatment, and change in BMI from baseline on and off treatment. Meta-analysis was conducted using RevMan (version 5.4) to calculate pooled mean…
Public
DrBob, Neurologist, 🧠Mechanic

Forget Psychedelics 😵‍💫

Everyone’s Microdosing Ozempic Now 🤔

“Shamoon has joined the wave of people who are taking limited amounts not of psychedelics — to which the microdosing trend usually applies — but of the diabetes drug #Ozempic (#semaglutide), and other #GLP1 receptor agonists like #Mounjaro

They are doing it not primarily for weight loss — the effect that has made Ozempic a Hollywood staple and a reliable awards-show punchline — but for the surprising and widely touted side benefits, particularly its anti-inflammatory properties”

hollywoodreporter.com/lifestyl

Text Shot: Dr. Caroline Messer, a top Manhattan endocrinologist, reported that many of the people asking her about microdosing have come in because they are genetically predisposed to Alzheimer’s. “The key is not decreased blood sugar,” she says, “but decreased inflammation. In patients without diabetes, it doesn’t lower blood sugar but still has an anti-inflammatory effect.” And, it makes sense, she notes, because “Alzheimer’s is sometimes referred to as Type 3 diabetes. The brain in someone with Alzheimer’s exhibits insulin resistance, similar to what is seen in Type 2 diabetes.” Microdosing can have a lasting effect in achieving a mental edge, says Dr. Anetta Reszko, a Park Avenue dermatologist. “Unlike traditional dosing, which primarily targets appetite suppression and glucose regulation, microdosing semaglutide may provide a more gradual, sustained effect on the brain, immune system and overall cellular health,” she notes. “By modulating these pathways, it may help reduce…
Public
Maggie Maybe

Someone I love was recently in the hospital for a week because her G.I. system pretty much shut down from using #Semaglutide.

Ladies, PLEASE UNDERSTAND, society doesn’t value thinness. Trust me, I have been petite and lean my entire life and all of society has spent 51 years trying to make me hate my body.

Society doesn’t want you to be thin, society just wants you to hate your body and spend a bunch of money trying to change it. Don’t fall for it.

It’s probably better to be heavy because people feel like it’s OK to be rude to your face if you are thin. At least if you’re heavy they are rude behind your back and not directly to your face.

#CapitalismKills
Public
DrBob, Neurologist, 🧠Mechanic

Good news re: GLP1 medications like #Zepbound (#tirzepatide) and #Wegovy (#semaglutide.)

Biden-⁠Harris Administration Takes Latest Step to Lower Prescription Drug Costs by Proposing Expanded Coverage of Anti-Obesity Medications for Americans with Medicare and Medicaid

whitehouse.gov/briefing-room/s

The White House · FACT SHEET: Biden-Harris Administration Takes Latest Step to Lower Prescription Drug Costs by Proposing Expanded Coverage of Anti-Obesity Medications for Americans with Medicare and Medicaid | The White HouseToday, the Biden-Harris Administration is proposing a new rule to significantly expand coverage of anti-obesity medications for Americans with Medicare
Public *
DrBob, Neurologist, 🧠Mechanic

Is this the FDA‘s backdoor to reduce the cost of drugs in America?

This opinion piece by Dr Scott Gottlieb, a Pfizer board member, may be biased towards the pharmaceutical industry 🤔

“#FDA’s permissive stance on the compounding of GLP-1 drugs used for weight loss. Initially, the agency cited shortages of #semaglutide and #tirzepatide — the active ingredients in the popular drugs #Wegovy and #Zepbound — and allowed pharmacies to compound these drugs under a provision for addressing drug shortages.

#obesity #glp1
statnews.com/2024/11/19/fda-gl

Text Shot: In many cases, however, the GLP-1 drugs are being compounded in pharmacies that are not required to meet these good manufacturing requirements. These are often smaller pharmacies that are permitted only to compound drugs for individual patients, with the expectation that the drugs will be used shortly after they are made. Yet they are compounding large volumes of drugs and shipping them across the country. Even in cases where outsourcing facilities produce these drugs, there are nagging questions about how pharmacies can obtain large volumes of the same active ingredients used in the brand drugs, raising concerns about the quality of compounded versions. Doctors often lack full knowledge of what these products contain, and patients can misunderstand what they are receiving, frequently assuming that compounded drugs are the same as brand alternatives.
Public
Martin Seeger

Through a friend I received this suprisingly well researched and differentiated video about semaglutide:

youtube.com/watch?v=_GPtQbeWW5

Lot of things I saw in (even well respected) news magazines was obvious bullshit.

My subjective and personal take on this drug can be found here: infosec.exchange/@masek/113107

YouTubeYou're Being Lied To About Ozempic | Truth Complex | Business InsiderBy Business Insider
#Ozempic#Wegovy#Semaglutide
Public
DrBob, Neurologist, 🧠Mechanic

#Obesity Drug Shows Promise in Easing Knee #Osteoarthritis Pain

As a practicing physician, I've seen up close the remarkable benefits of the #GLP1 class of medications, including #semaglutide (#Ozempic, #Wegovy) and #tirzepatide (#Mounjaro, #Zepbound.)

Reduction in weight (and inflammation) are game changers.

Better control of #Diabetes, reduced #Cardiovascular and #Stroke risk, maybe lower incident of #Dementia, #MultipleSclerosis and other diseases which have an 'inflammatory' component.

All we need now is to lower the cost (about $1,000/month in the US; heard the price is $59 in EU!)

nytimes.com/2024/10/30/health/

Public
Auscandoc

News Details novonordisk.com/news-and-media novonordisk.com/content/nncorp “The key objective of SOUL was to demonstrate that oral #semaglutide lowers the risk of major adverse #cardiovascular events (a composite endpoint consisting of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) compared to placebo, both added to standard of care in patients with type 2 #diabetes and established CVD and/or CKD.”

#Rybelsus has lift off @ChristosArgyrop ?

Novo NordiskNews Details
Public
kurtsh

Philosophically, I absolutely get that pharmaceutical research is outrageously costly (esp. w/ FDA precautions) & that the richest country in the world needs to lead the charge & pick up the tab for those that can't.

BUT JESUS. 10X ON AVERAGE?

I'm taking this awful tasting crap to stay healthy enough to see my son graduate - not to "slim down for the Oscars red carpet" or some bullshit that people think these drugs are usually taken for...

#pharmaceuticals#healthcare#semaglutide
Public
Martin Kostera
Probíral jsem s kámošem ty moje levné náhražky Saxendy, Ozempicu a Mounjara. Poslal jsem mu tu svou "rešerši" a sepsul mě, že jsem neuvedl obyčejné kvasnice. Obyčejné droždí. Málem jsem se pozvracel. 🤮😂
A to prosím neznám osobně druhou osobu, která by droždí jedla, než moje mamka a vždy jsem prchal, abych to neviděl. 😁

Ale je to fakt. Je to extrémně levné. 42g(2g je ten hliníkový obal, bych řekl) balení stojí 5-12 kaček. Je z toho cca 20g čistého betaglukanu, což je skoro ta jedna pomyslná dávka, kterou simulují léky na hubnutí. Takže jedna krychlička denně.

#^https://www.rohlik.cz/1289859-uniferm-drozdi-cerstve
#^https://www.rohlik.cz/1305551-fala-pekarske-drozdi-cerstve

Jako jo, jde to, ale já bych to do sebe nedostal ani párem volů. To raději chroupat půl kila ovsa denně... 🐎

Více viz:
#^https://libera.site/item/a55497fa-97b2-4172-8105-2a7b91c7bd5c

#Betaglukan #Ozempic #Saxenda #Mounjaro #Semaglutide #Liraglutide #Tirzepatide #Kvasnice #Droždí
Rohlik.czUniferm droždí čerstvéČerstvé pekařské droždí neboli kvasnice. PoužitíKvasnice se používají pro pečení chleba a pečiva z kynutého těsta.O výrobciSpolečnost UNIFERM se může
#drozdi
Public
DrBob, Neurologist, 🧠Mechanic

Who needs a #GLP1 when you have this? Move over Ozempic!

"We've developed a molecule that can mimic the body's natural metabolic response to strenuous exercise and fasting.

In practice, the molecule brings the body into a metabolic state corresponding to running 10 kilometers at high speed on an empty stomach," explains Professor Thomas Poulsen from the Department of Chemistry at Aarhus University"

#ozempic #mounjaro #zepbound #wegovy #tirezepatide #semaglutide #obesity #weightloss #longevity
phys.org/news/2024-10-molecule

Phys.org · New molecule can mimic the effects of fasting and exerciseBy Aarhus University
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